ZHANG’s LAB @HKUST
2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011
2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 199X
Year 2022
  • Lv, P., Du, Y., He, C., Zhou, X., Zeng, M., Li, C., Zhang, M., Dong, S., and Chen, X. (2022) "O-GlcNAcylation modulates liquid-liquid phase separation of SynGAP/PSD-95" Nat Chem (in press)
     
  • Ravi, A., Zeng, M., Chen, C., Sandoval, G., Diaz-Alonso, J., Zhang, M., and Nicoll, R.A (2022) “Long-term potentiation reconstituted with an artificial TARP/PSD-95 complex” Cell Rep (in press).
     
  • Bai, G. and Zhang, M. (2022) “Inhibitory postsynaptic density from the lens of phase separation” Oxford Open Neurosci (in press)
     [Abstract] PDF Full Version
     
  • Cinar, H., Oliva, R., Wu, H., and Zhang, M., Chan, H.S., and Winter, R. (2022) “Effects of Cosolvents and Crowding Agents on the Stability and Phase Transition Kinetics of the SynGAP/PSD-95 Condensate Model of Postsynaptic Densities” J Phys Chem B. 126, 1734-1741.
     [Abstract] PDF Full Version
     
  • Lin, Y.H., Wu, H., Jia, B., Zhang, M., and Chan, H.S. (2022) “Assembly of model postsynaptic densities involves interactions auxiliary to stoichiometric binding” Biophys J 121, 157-171.
     [Abstract] PDF Full Version
     
Year 2021
  • Vistrup-Parry, M., Chen, X., Johansen, T.L., Bach, S., Buch-Larsen, S.C., Bartling, C.R.O., Ma, C., Clemmensen, L.S., Nielsen, M.L., Zhang, M., and Strømgaard, K. (2021) “Site-specific phosphorylation of PSD-95 dynamically regulates the postsynaptic density as observed by phase separation” iScience 24, 103268.
     [Abstract] PDF Full Version
     
  • Unarta, I.C., Xu, J., Shang, Y., Cheung, C.H.P., Zhu, R., Chen, X., Cao, S., Cheung, P.P., Bierer, D., Zhang, M., Huang, X., and Li, X. (2021) “Entropy of stapled peptide inhibitors in free state is the major contributor to the improvement of binding affinity with the GK domain”RSC Chem Biol. 2, 1274-1284.
     [Abstract] PDF Full Version
     
  • Zhang, H., Lin, L., Liu, J., Pan, L., Lin, Z., Zhang, M., Zhang, J., Cao, Y., Zhu, J., and Zhang, R. (2021) “Phase Separation of MAGI2-Mediated Complex Underlies Formation of Slit Diaphragm Complex in Glomerular Filtration Barrier” J Am Soc Nephrol. 32, 1946-1960.
    [Abstract]
     
  • Feng, Z., Jia, B., and Zhang, M.(2021) “Liquid-Liquid Phase Separation in Biology: Specific Stoichiometric Molecular Interactions vs Promiscuous Interactions Mediated by Disordered Sequences”Biochemistry 60, 2397-2406.
    [Abstract] PDF Full Version
     
  • Feng, Z., Wu, X., and Zhang, M.(2021) "Presynaptic bouton compartmentalization and postsynaptic density-mediated glutamate receptor clustering via phase separation."Neuropharmacology, 108622.
     [Abstract] PDF Full Version
     
  • Bai G, Zhang, M.(2021). "Clustering acetylcholine receptors in neuromuscular junction by phase-separated Rapsn condensates." Neuron. 109(12):1907-1909.
    [Abstract] PDF Full Version
     
  • Hosokawa, T., Liu, P. W., Cai, Q., Ferreira, J. S., Levet, F., Butler, C.,Sibarita,J.B., Choquet, D., Groc,L., Hosy,E., Zhang, M. & Hayashi, Y. (2021). "CaMKII activation persistently segregates postsynaptic proteins via liquid phase separation."Nature Neuroscience , 1-9.
     [Abstract] PDF Full Version
     
  • Wang, X., Ye, F., Wen, Z., Guo, Z., Yu, C., Huang, W. K., Ringeling, F.R.,Su,Y.,Zheng, W.,Zhou, G., Song, H.,Zhang, M., & Ming, G. L. (2019). "Structural interaction between DISC1 and ATF4 underlying transcriptional and synaptic dysregulation in an iPSC model of mental disorders. "Molecular psychiatry, 1-15.
     [Abstract] PDF Full Version
     
  • Chen, W., Shen, Z., Asteriti, S., Chen, Z., Ye, F., Sun, Z., Wan,J. Montell,C. Hardie, R. Liu, W. & Zhang, M. (2021). "Calmodulin binds to Drosophila TRP with an unexpected mode. " Structure, 29(4), 330-344.
     [Abstract] PDF Full Version
     
  • Bai, G., Wang, Y., and Zhang, M.(2021) "Gephyrin-mediated formation of inhibitory postsynaptic. density sheet via phase separation " Cell Research, 1-14.
     [Abstract] PDF Full Version
     
  • Zhou, S., Han, L., Weng, M., Zhu, H., Heng, Y., Wang, G., ... Zhang, M., and Wu, Z.(2021) "Paxbp1 controls a key checkpoint for cell growth and survival during early activation of quiescent muscle satellite cells ." Proceedings of the National Academy of Sciences, 118(13).
     [Abstract] PDF Full Version
     
  • Zang, J., Ye, F., Solbak, S. M., Høj, L. J., Zhang, M., & Bach, A. (2021). "Identification of novel fragments binding to the PDZ1‐2 domain of PSD‐95. "ChemMedChem, 16(6), 949-954.
     [Abstract] PDF Full Version
     
  • Hayashi, Y., Ford, L. K., Fioriti, L., McGurk, L., & Zhang, M. (2021)." Liquid-liquid phase separation in physiology and pathophysiology of the nervous system. "Journal of Neuroscience, 41(5), 834-844.
     [Abstract] PDF Full Version
     
  • Cai, Q., Zeng, M., Wu, X., Wu, H., Zhan, Y., Tian, R., Zhang, M.(2021) "CaMKIIα-driven, phosphatase-checked postsynaptic plasticity via phase separation." Cell Research, 1-15.
     [Abstract] PDF Full Version
     
  • Ye, J., Zou, G., Zhu, R., Kong, C., Miao, C., Zhang, M., Li,J. Xiong,W.& Wang, C. (2021). "Structural basis of GABARAP-mediated GABA A receptor trafficking and functions on GABAergic synaptic transmission."Nature communications , 12(1), 1-12.
     [Abstract] PDF Full Version
     
  • Wu, X., Ganzella, M., Zhou, J., Zhu, S., Jahn, R., Zhang, M.(2021) "Vesicle Tethering on the Surface of Phase-Separated Active Zone Condensates." Molecular Cell.
     [Abstract] PDF Full Version
     
  • Bai, G., & Zhang, M. (2021). "Mesophasic Assembly of Inhibitory Postsynaptic Density. "Neuroscience Bulletin, 37(1), 141-143.
     [Abstract] PDF Full Version
     
Year 2020
  • Lin, Z., Xie, R., Guan, K., and Zhang, M.(2020) "A WW tandem-mediated dimerization mode of SAV1 essential for Hippo signaling."Cell Reports, 32(10), 108118.
     [Abstract] PDF Full Version
     
  • Zhu, J., Zhou, Q., Xia, Y., Lin, L., Li, J., Peng, M., Zhang, R., and Zhang, M.(2020) "GIT/PIX condensates are modular and ideal for distinct compartmentalized cell signaling ". Mol Cell, (2020).
     [Abstract] PDF Full Version
     
  • Wu, X., Cai, Q., Feng, Z., and Zhang, M.(2020) "Liquid-liquid phase separation in neuronal development and synaptic signalling ". Dev Cell, [invited review].
     [Abstract] PDF Full Version
     
  • Chen, K., Yang, R., LI, Y., Zhou, J.C., and Zhang, M.(2020) "Giant ankyrin-B suppresses stochastic collateral axon branching via interaction with microtubules ". J Cell Biol 219(8).
    [Abstract] PDF Full Version
     
  • Li, J., Chen, K., Zhu, R., and Zhang, M.(2020) "Structural basis underlying strong interactions between ankyrins and spectrins ". J Mol Biol, 432, 3838-3850.
     [Abstract] PDF Full Version
     
  • Wu, X., Cai, Q., Chen, Y., Zhu, S., Mi, J., Wang, J., and Zhang, M.(2020) "Structural basis for the high affinity interaction between CASK and Mint1 ". Structure, 28, 664-673.
     [Abstract] PDF Full Version
     
  • Zhang, H., Ji, X., Li, P., Liu, C., Lou, J., Wang, Z., Wen, W., Xiao, Y., Zhang, M., Zhu, X.(2020) "Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases". Sci China Life Sci, 63, 953-985[invited revirew].
     [Abstract] PDF Full Version
     
  • Yu, T., Kuang, H., Chen, J., Lin, X., Wu, Y., Chen, K., Zhang, M., Zhang, W., and Wen, Z. (2020) "Tripartite-motif Family Protein 35-28 Regulates Microglia Development by Preventing Necrotic Death of Microglial Precursors in Zebrafish". J Biol Chem 295.26: 8846-8856.
    [Abstract] PDF Full Version
     
  • Liu, Z., Yang, Y., Gu, A., Xu, J., Mao, Y., Lu, H., Hu, W., Lei, Q.-Y., Li, Z., Zhang, M., Cai, Y., and Wen, W. .(2020) "Par complex cluster formation mediated by phase separation ". Nat Commun, 11:2266.
     [Abstract] PDF Full Version
     
  • Cai, Q., Hosokawa, T., Zeng, M., Hayashi, Y., and Zhang, M.(2020) "Shank3 binds to and stabilizes the active form of Rap1 and HRas GTPases via its NTD-ANK tandem with distinct mechanisms ". Structure, 290, 290-300.
     [Abstract] PDF Full Version
     
  • Ye, J., Li. J., Ye, F., Zhang, Y., Zhang, M., and Wang, C.(2020) "Mechanistic insights into the interactions of dynein regulator Ndel1 with neuronal ankyrins and implications in polarity maintenance ". PNAS, 117, 1207-1215.
     [Abstract] PDF Full Version
     
  • Chen, X., Wu, X., Wu, H., and Zhang, M.(2020) "Phase separation at the synapse ". Nat Neurosci, 23, 301-310.[invited review]
     [Abstract] PDF Full Version
     
  • Hong, A.W, Meng, Z., Plouffe, S.W., Lin, Z., Zhang, M., and Guan, K.-L. (2020) "Critical roles of phosphoinositides and NF2 in Hippo pathway regulation ". Gene Dev, 34, 511-525.
     [Abstract] PDF Full Version
     
  • Cinar, H., Oliva, R., Lin, Y.H., Chen, X., Zhang, M., Chan, H.S., and Winter, R. (2020) "Pressure Sensitivity of SynGAP/PSD-95 Condensates as a Model for Postsynaptic Densities and its Biophysical and Neurological Ramifications ". Chemistry, 26.48: 11024-11031.
     [Abstract] PDF Full Version
     
Year 2019
  • He, Y., Li, J., and Zhang, M.(2019) "Myosin VII, USH1C and ANKS4B (or USH1G) together form condensed molecular assembly via liquid-liquid phase separation ." Cell Rep, 29, 974-986.
     [Abstract] PDF Full Version
     
  • Lin, Z., Yang, Z., Xie, R., Ji, Z., Guan, K., and Zhang, M.(2019) "Decoding WW domain tandem-mediated target recognitions in tissue growth and cell polarity ." eLife, 8, e49439.
     [Abstract] PDF Full Version
     
  • Zeng, M., Díaz-Alonso, J., Ye, F., Chen, X., Xu, J., Ji, Z., Nicoll, RA., and Zhang, M.(2019) "Phase Separation-Mediated TARP/MAGUK Complex Condensation and AMPA Receptor Synaptic Transmission ." Neuron, 104, 1-15.
     [Abstract] PDF Full Version
     
  • Wang, X., Ye, F., Wen, Z., Guo, Z., Yu, C., ... Song, H., and Zhang, M., Ming, G.(2019) "Structural interaction between DISC1 and ATF4 underlying transcriptional and synaptic dysregulation in an iPSC model of mental disorders ". Molecular Psychiatry, 1-15.
     [Abstract] PDF Full Version
     
  • Feng, Z., Chen, X., Wu, X., and Zhang, M.(2019) "Formation of biological condensates via phase separation: Characteristics, analytical methods, and physiological implications". Journal of Biological Chemistry, 294.40.14823-14835.
     [Abstract] PDF Full Version
     
  • Liu, H., Li, Z., Yang, Q., Liu, W., Wan, J., Li, J., and Zhang, M.(2019) "Substrate Docking-mediated Specific and Efficient Lysine Methylation by the SET domain-containing histone methyltransferase SETD7". Journal of Biological Chemistry, 294.36.13355-13365.
     [Abstract] PDF Full Version
     
  • Li, J., Liu, H., Raval, M., Wan, J., Yengo, C., Liu, W., and Zhang, M.(2019) "Structure of the MORN4/Myo3a Tail Complex Reveals MORN Repeats as Protein Binding Modules". Structure, 27, 1–9.
     [Abstract] PDF Full Version
     
  • Wang, T., Yan, B., Lou, L., Lin, X., Yu, T., Wu, S., Lu, Q., Liu, W., Huang, Z., Zhang, M. and Wen, Z.(2019) "Nlrc3-like is required for microglia maintenance in zebrafish". Journal of Genetics and Genomics, 46(6), 291–299..
     [Abstract] PDF Full Version
     
  • Jin, W., Dai, Y., Li, F., Zhu, L., Huang, Z., Li, J., Zhang, M., Du, J., Zhang, W., and Wen, Z.(2019) "Dysregulation of Microglial Function Contributes to Neuronal Impairment in Mcoln1a-Deficient Zebrafish". iScience, 13, 391–401..
     [Abstract] PDF Full Version
     
  • Tao, W., Ma, C., Bemben, M., Li, K., Burlingame, A., Zhang, M. and Nicoll, R.(2019) "Mechanisms underlying the synaptic trafficking of the glutamate delta receptor GluD1". Molecular Psychiatry.
     [Abstract] PDF Full Version
     
  • Ji, Z., Li, H., Yang, Z., Huang, X., Ke, X., Ma, S., Lin, Z., Lu, Y., and Zhang, M.(2019) "Kibra Modulates Learning and Memory via Binding to Dendrin". Cell Reports, 26, 2064–2077.
     [Abstract] PDF Full Version
     
  • Wu, X., Cai, Q., Shen, Z., Chen, X., Zeng, M., Du, S., and Zhang, M.(2019) "RIM and RIM-BP Form Presynaptic Active-Zone-like Condensates via Phase Separation". Molecular Cell, 73, 1-14.
     [Abstract] PDF Full Version
     
  • Li, Z., Liu, H., Li, J., Yang, Q., Feng, Z., Li, Y., Yang, H., Yu, C., Wan, J., Liu, W., and Zhang, M.(2019) "Homer Tetramer Promotes Actin Bundling Activity of Drebrin". Structure, 27(1), 27-38.
     [Abstract] PDF Full Version
     
  • Feng, Z., Chen, X., Zeng, M., and Zhang, M.(2018) "Phase separation as a mechanism for assembling dynamic postsynaptic density signalling complexes". Current Opinion in Neurobiology, 57, 1-8.
     [Abstract] PDF Full Version
     
Year 2018
  • Ye, F., Huang, Y., Li, J., Ma, Y., Xie, C., Liu, Z., Deng, X., Wan, J., Xue, T., Liu, W., and Zhang, M.(2018) "An unexpected INAD PDZ tandem-mediated plcβ binding in Drosophila photo receptors". eLife, 7, e41848.
     [Abstract] PDF Full Version
     
  • Nelson, A. D., Caballero-Florán, R. N., Rodríguez Díaz, J. C., Hull, J. M., Yuan, Y., Chen, K., ..., Wang, C., Zhang, M., Jones, K. S., and Jenkins, P. M.,(2018) "Ankyrin-G regulates forebrain connectivity and network synchronization via interaction with GABARAP". Molecular Psychiatry, 1.
     [Abstract] PDF Full Version
     
  • Zeng, M., Chen, X., Guan, D., Xu, J., Wu, H., Tong, P., and Zhang, M.(2018) "Reconstituted Postsynaptic Density as a Molecular Platform for Understanding Synapse Formation and Plasticity". Cell, 174, 1-16.
     [Abstract] PDF Full Version
     
  • Xu, Z., Lo, W., ... and Zhang, M.,..., and Schimmel, P.,(2018) "Bi-allelic Mutations in Phe-tRNA Synthetase Associated with a Multi-system Pulmonary Disease Support Non-translational Function". The American Journal of Human Genetics, 103, 100-114.
     [Abstract] PDF Full Version
     
  • Li, J., Zhu, R., Chen, K., Zheng, H., Zhao, H., Yuan, C., Zhang, H., Wang, C., and Zhang, M.(2018) "Potent and specific Atg8-targeting autophagy inhibitory peptides from giant ankyrins". Nature Chemical Biology, 14, pages778–787.
     [Abstract] PDF Full Version
     
  • Wang, Y., Shang, Y., Li, J., Chen, W., Li, G., Wan, J., Liu, W., and Zhang, M.(2018) "Specific Eph receptor-cytoplasmic effector signaling mediated by SAM–SAM domain interactions". eLife, 7, e35677.
     [Abstract] PDF Full Version
     
  • Feng, Z., Zeng, M., Chen, X., and Zhang, M.(2018) "Neuronal Synapses: Microscale Signal Processing Machineries Formed by Phase Separation?". Biochemistry, 57(17), pp 2530–2539.
     [Abstract] PDF Full Version
     
  • Shan, Z., Tu, Y., Yang, Y., Liu, Z., Zeng, M., Xu, H., Long, J., Zhang, M., Cai, Y. and Wen, W.(2018) "Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division". Nature Communications, 9, 737.
     [Abstract] PDF Full Version
     
  • Zeng, M., Ye, F., Xu, J., and Zhang, M.(2018) "PDZ Ligand Binding-Induced Conformational Coupling of the PDZ–SH3–GK Tandems in PSD-95 Family MAGUKs". Journal of Molecular Biology, 430(1), 69-86.
     [Abstract] PDF Full Version
     
Year 2017
  • Zhu, J., Zhou, Q., Shang, Y., Li, H., Peng, M., Ke, X., ... and Zhang, M.(2017) "Synaptic Targeting and Function of SAPAPs Mediated by Phosphorylation-Dependent Binding to PSD-95 MAGUKs". Cell Reports, 21(13), 3781-3793.
     [Abstract] PDF Full Version
     
  • Ye, F., Kang, E., Yu, C., Qian, X., Jacob, F., Yu, C., ... Song, H., Ming, G., and Zhang, M.(2017) "DISC1 regulates neurogenesis via modulating kinetochore attachment of Ndel1/Nde1 during mitosis". Neuron, 114(41), E8760-E8769.
     [Abstract] PDF Full Version
     
  • Zhang, L., Jablonski, A. M., Mojsilovic-Petrovic, J., Ding, H., Seeholzer, S., Newton, I. P., ... Shang, Y., Zhang, M., and Kalb, R. G.(2017) "SAP97 Binding Partner CRIPT Promotes Dendrite Growth In Vitro and In Vivo". eNeuro, 4(6), ENEURO-0175.
     [Abstract] PDF Full Version
     
  • Yao, N., Li, J., Liu, H., Wan, J., Liu, W., and Zhang, M.(2017) "The Structure of the ZMYND8/Drebrin Complex Suggests a Cytoplasmic Sequestering Mechanism of ZMYND8 by Drebrin". Structure, 25(11), 1657-1666.
     [Abstract] PDF Full Version
     
  • Ma, Q., Ruan, H., Peng, L., Zhang, M., Gack, M. U., and Yao, W. D.(2017) "Proteasome-independent polyubiquitin linkage regulates synapse scaffolding, efficacy, and plasticity". PNAS, 114(41), E8760-E8769.
     [Abstract] PDF Full Version
     
  • Wen, W., and Zhang, M.(2017) "Protein complex assemblies in epithelial cell polarity and asymmetric cell division". Journal of Molecular Biology.
     [Abstract] PDF Full Version
     
  • Pedersen, S. W., Albertsen, L., Moran, G. E., Levesque, B., Pedersen, S. B., Bartels, L., Wapenaar, H., Ye, F., Zhang, M., and Bowen, M. E., and Strømgaard, K.(2017) "Site-Specific Phosphorylation of PSD-95 PDZ Domains Reveals Fine-Tuned Regulation of Protein–Protein Interactions". ACS chemical biology, 12(9), 2313-2323.
     [Abstract] PDF Full Version
     
  • Ye, F., Zeng, M., and Zhang, M.(2017) "Mechanisms of MAGUK-mediated cellular junctional complex organization". Current Opinion in Structural Biology, 48, 6-15.
     [Abstract] PDF Full Version
     
  • Chen, K., LI, J., Wang, C., Wei, Z and Zhang, M.(2017) "Autoinhibition of ankyrin-B/G membrane target bindings by intrinsically disordered segments from the tail regions". eLife, 6.
     [Abstract] PDF Full Version
     
  • Liu, M., Ji, Z., Zhang, M., and Xia, J.(2017) "Versatile site-selective protein reaction guided by WW domain–peptide motif interaction". Bioconjugate chemistry, 28(8), 2199-2205.
     [Abstract] PDF Full Version
     
  • Zeng, M., Bai, G., and Zhang, M.(2017) "Anchoring high concentrations of SynGAP at postsynaptic densities via liquid-liquid phase separation". Small GTPases (published online on May. 19).
     [Abstract] PDF Full Version
     
  • Li, J., He, Y., Weck, M. L., Lu, Q., Tyska, M. J., and Zhang, M.(2017) "Structure of Myo7b/USH1C complex suggests a general PDZ domain binding mode by MyTH4-FERM myosins". PNAS 114(19), 3776-2785.
     [Abstract] PDF Full Version
     
  • Li, J., Chen, Y., Deng, Y., Unarta, I. C., Lu, Q., Huang, X., and Zhang, M.(2017) "Ca2+-Induced Rigidity Change of the Myosin VIIa IQ Motif-Single α Helix Lever Arm Extension". Structure 25, 579–591.
     [Abstract] PDF Full Version
     
  • Swayne, L. A., Murphy, N. P., Asuri, S., Chen, L., Xu, X., McIntosh, S., Wang, C., ... and Zhang, M., Mohler, P. J., Arbour, L. T.(2017) "Novel Variant in the ANK2 Membrane-Binding Domain Is Associated With Ankyrin-B Syndrome and Structural Heart Disease in a First Nations Population With a High Rate of Long QT Syndrome". Circulation: Cardiovascular Genetics, 10(1), e001537.
     [Abstract] PDF Full Version
     
Year 2016
  • Zhu, J., Shang, Y., Xia, Y., Zhang, R., and Zhang, M.(2016) "An atypical MAGUK GK target recognition mode revealed by the interaction between DLG and KIF13B". Structure (published online on Sept. 15) doi: 10.1016/j.str.2016.08.008.
     [Abstract] PDF Full Version
     
  • Zeng, M. Shang, Y., Araki, Y., Guo, T., Huganir, R. L., and Zhang, M.(2016) "Phase transition in postsynaptic densities underlies formation of synaptic complexes and synaptic plasticity". Cell 166, 1163-1175.
     [Abstract] PDF Full Version
     
  • Zeng, M., Shang, Y., Guo, T., He, Q., Yung, W.-H., Liu, K., and Zhang, M.(2016) "A new binding site outside the canonical PDZ domain determines the specific interaction between Shank and SAPAP and their function in synapses". PNAS 113, E3081-3090.
     [Abstract] PDF Full Version
     
  • Zhu, J., Shang, Y. and Zhang, M.(2016) "Mechanistic basis of MAGUK-organized complexes in synaptic development and signalling" [invited review]. Nat Rev Neurosci 17,209-223.
     [Abstract] PDF Full Version
     
  • Zhou, Y., Kaiser, T., Monteiro, P., Zhang, X., Van der Goes, M.S., Wang, D., Barak, B., Zeng, M., Li, C., Lu, C., Wells, M., Amaya, A., Nguyen, S., Lewis, M., Sanjana, N., Zhou, Y., Zhang, M., Zhang, F., Fu, Z., and Feng, G. (2016) "Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects". Neuron 89,147-162.
     [Abstract] PDF Full Version
     
  • Li, J., He, Y., Lu, Q., and Zhang, M. (2016) "Mechanistic Basis of Organization of the Harmonin/USH1C-Mediated Brush Border Microvilli Tip-Link Complex". Dev Cell 36, 179-189.
     [Abstract] PDF Full Version
     
  • Ye, F., Liu, W., Shang, Y. and Zhang, M. (2016) "An Exquisitely Specific PDZ/target Recognition Revealed by the Structure of INAD PDZ3 in Complex with TRP Channel Tail"[Cover article] Structure 24, 383-391.
     [Abstract] PDF Full Version
     
  • Liu, H., Li, J., Raval, M. H., Yao, N., Deng, X., Lu, Q., Nie, S., Feng, W., Wan, J., Yengo, C. M., Liu, W., and Zhang, M. (2016) "Myosin III-mediated Cross-linking and Stimulation of Actin Bundling Activity of Espin" eLife 5, pii: e12856.
     [Abstract] PDF Full Version
     
  • Wei Z., Xu Z., Liu X., Lo W.S., Ye F., Lau C.F., Wang F., Zhou J.J., Nangle L.A., Yang X.L., Zhang M, Schimmel P. (2016) "Alternative splicing creates two new architectures for human tyrosyl-tRNA synthetase" Nucleic Acid Res   44, 1247-1255.
     [Abstract] PDF Full Version
     
  • Li, J., Lu, Q., and Zhang, M. (2016) "Structural Basis of Cargo Recognition by Unconventional Myosins in Cellular Trafficking"Traffic 22, 81-88.
    [Abstract] PDF Full Version


Year 2015
  • Jia, M., Shan, Z., Yang, Y., Liu, C., Li, J., Luo, Z., Zhang, M., Cai, Y., Wen, Y., and Wang, W. (2015) "The structural basis of Miranda mediated Staufen localization during Drosophila neuroblast asymmetric division" Nat Comms 6,8381.
     [Abstract] PDF Full Version
     
  • Huang, F.,m Nie, Y., Ye, F.,Zhang, M.and Xia, J. (2015) "Site Selective Azo Coupling for Peptide Cyclization and Affinity Labeling of an SH3 Protein" Bioconjug Chem 26,1613-1622.
     [Abstract] PDF Full Version
     
  • Lorenzo, D. N., Healy, J. S., Hostettler, J., Davis, J., Yang, J., Hohmeier, H. E., Wang, C., Zhang, M. and Bennett, V. (2015) "Ankyrin-B metabolic syndrome combines age-dependent adiposity with pancreatic ß cell insufficiency" J Clin Invest 125, 3087-3102.
     [Abstract] PDF Full Version
     
  • Li, Y., Zhou, H., Li, F., Chan, S.W., Lin, Z., Wei, Z., Yang, Z., Guo, F., Lim, C.J., Xing, W., Shen, Y., Hong, W., Long, J., and Zhang, M(2015) "Angiomotin Binding-induced Activation of Merlin/NF2 in the Hippo Pathway" Cell Res 25,801-817.
     [Abstract] PDF Full Version
     
  • Li, L.-L., Melero-Fernandez de Mera, R., Chen, J., Ba, W., Kasri, N.N., Zhang, M., and Courtney, M. ((2015) "Unexpected heterodivalent recruitment of NOS1AP to nNOS reveals multiple sites for pharmacological intervention in neuronal disease models" J Neurosci 35,7349-6364.
     [Abstract] PDF Full Version
     
  • Wei, Z., Li, Y.,Ye, F., and Zhang, M. (2015) "Structural basis for the phosphorylation-regulated interaction between the cytoplasmic tail of cell polarity protein Crumbs and the actin binding protein Moesin" J. Biol. Chem. 290, 11384-11392.
     [Abstract] PDF Full Version
     
  • Smith, S.A., Sturm, A.C., Curran, J., Kline, C.F., Little, S.C., Bonilla, I.M., Long, V.P., Makara, M., Polina, I., Hughes, L.D., Webb. T.R., Wei, Z., Wright, P., Voigt, N., Bhakta, D., Spoonamore, K.G., Zhang, C., Weiss, R., Binkley, P.F., Janssen, P.M., Kilic, A., Higgins, R.S., Sun, M., Ma, J., Dobrev, D., Zhang, M.,Carnes, C.A., Vatta, M., Rasband, M.N., Hund, T.J., and Mohler, P.J. (2015) "Dysfunction in the ßII Spectrin-Dependent Cytoskeleton Underlies Human Arrhythmia". Circulation 131, 695-708.
     [Abstract] PDF Full Version
     
  • Eildal, J.N.N., Bach, A., Dogan, J., Ye, F., Zhang,M.,Jemth, P., and Stromgaard, K. (2015) "Rigidified clicked dimeric ligands for studying the dynamics of the PDZ1-2 supramodule of PSD-95" ChemBioChem 16, 64-69.
     [Abstract] PDF Full Version
     
  • Araki, Y., Zeng, M.,Zhang, M., and Huganir, R. L. (2015) "Rapid Dispersion of SynGAP from Synaptic Spines TriggersAMPA Receptor Insertion and Spine Enlargement During LTP" Neuron   85, 173-189.
     [Abstract] PDF Full Version
     
  • Lu, Q., Li, J., Ye, F., and Zhang, M. (2015) "Structure of myosin-1c tail bound to calmodulin provides insights into calcium-mediated conformational coupling"Nat Struct Mol Biol 22, 81-88.
    [Abstract] PDF Full Version


Year 2014
  • Wang, C., Wei, Z., Chen, K., Ye, F., Yu, C., Bennett, V., and Zhang, M. (2014) "Structural Basis of Diverse Membrane Target Recognitions by Ankyrins" eLife 3:e04353.
     [Abstract] PDF Full Version
     
  • Li, Y., Wei, Z., Yan, Y., Wan, Q., Du, Q., and Zhang, M. (2014) "Structure of Crumbs tail in complex with PALS1 PDZ-SH3-GK tandem reveals a specific assembly mechanism for the apical Crumbs complex" P.N.A.S. 111, 17444-17449.
    [Abstract] PDF Full Version
     
  • Jehi, S. E., Li, X., Sandhu, R., Ye, F., Benmerzouga, I., Zhang, M., Zhang, Y., and Li, B. (2014) "Suppression of subtelomeric VSG switching by Trypanosoma brucei TRF requires its TTAGGG repeat-binding activity" Nucl Acids Res 42(20), 12899–12911.
     [Abstract] PDF Full Version
     
  • Lu, Q., Li, J., and Zhang, M. (2014) "Cargo Recognition and Cargo-mediated Regulation of Unconventional Myosins" Acc Chem Res 47, 3061-3070.
     [Abstract] PDF Full Version
     
  • Yan, B., Han, P., Pan, L., Lu, W., Xiong, J., Zhang, M., Zhang, W., Li, L., and Wen, Z. (2014) "IL-1β and reactive oxygen species differentially regulate neutrophil directional migration and Basal random motility in a zebrafish injury-induced inflammation model". J Immunol. 192, 5998-6008.
     [Abstract] PDF Full Version
     
  • Zhou, J.J., Wang, F., Xu, Z., Lo, W.-S., Lau, C.F., Chiang, K.P., Nangle, L.A., Ashlock, M.A., Mendlein, J.D., Yang, X.-L., Zhang, M., and Schimmel, P. (2014) "Secreted Histidyl-tRNA Synthetase Splice Variants Elaborate Major Epitopes for Autoantibodies in Inflammatory Myositis". J. Biol. Chem. 289, 19269-19275.
     [Abstract] PDF Full Version
     
  • Lo, W.-S., Gardiner, E., Xu, Z., Lau, C.-F., Wang, F., Zhou, J. J., Mendlein, J. D., Nangle, L. A., Chiang, K. P., Yang, X.-L., Au, K.-F., Wong, W. H., Guo, M., Zhang, M., and Schimmel, P. (2014) "Human tRNA synthetase catalytic nulls with diverse functions". Science  345, 328-332.
     [Abstract] PDF Full Version
     
  • Li, Y., Wei, Z., Zhang, J., Yang, Z., and Zhang, M. (2014) "Structural Basis of the Binding of Merlin FERM Domain to the E3 Ubiquitin Ligase Substrate Adaptor DCAF1". J Biol Chem, 289, 14674-14681.
    [Abstract] PDF Full Version

  • Piccoli, G., Onofri, F., Cirnaru, M. D., Kaiser, C. J., Jagtap, P., Kastenmuller, A., Pischedda, F., Marte, A., von Zweydorf, F., Vogt, A., Giesert, F., Pan, L., Antonucci, F., Kiel, C., Zhang, M., Weinkauf, S., Sattler, M., Sala, C., Matteoli, M., Ueffing, M., and Gloeckner, C. J.  (2014) "LRRK2 binds to neuronal vesicles through protein interactions mediated by its C-terminal WD40 domain".  Mol Cell Biol ,35, 2147-2161.
    [Abstract] PDF Full Version

  • Zhu, J., Shang, Y., Wan, Q., Xia, Y., Chen, J., Du, Q., and Zhang, M. (2014) "Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl".  Cell Res ,24, 451-463.
    [Abstract] PDF Full Version

Year 2013
  •  Wang, F., Xu, Z., Lo, W.-S., Lau, C.-F., Nangle, L. A., Yang, X.-L.,Zhang, M.,Schimmel,P.(2013) "Regulated capture by exosomes of mRNAs for cytoplasmic tRNA synthetases." J Biol Chem, 288, 29223-29228
    [Abstract] PDF Full Version

  •  Ye, F, and Zhang, M. (2013) "Structures and Target Recognition Modes of PDZ Domains: recurring themes and emerging pictures" Biochem J, 455,1-14.[invited review]
    [Abstract] PDF Full Version

  •  Wei, Z., Liu, X., Yu, C., and Zhang, M. (2013) "Structural Basis of Cargo Recognitions for Class V Myosins" PNAS 110, 11314-11319.
    [Abstract] PDF Full Version

  •  Pan, Z., Zhu, J., Shang, Y., Wei, Z., Jia, M., Xia, C., Wen, W., Wang, W., and Zhang, M. (2013) "An auto-inhibited conformation of LGN reveals a distinct interaction mode between GoLoco motifs and TPR motifs" Structure 21, 1007-017.
    [Abstract] PDF Full Version

  •  Zhang, Y., Wang, W., Chen, J., Zhang, K., Gao, F., Gao, B., Zhang, S., Dong, M., Besenbacher, F., Gong, W., Zhang, M., Sun, F., and Feng, W. (2013) "Structural Insights into the Intrinsic Self-Assembly of Par-3 N-Terminal Domain"  Structure  21, 997-1006.
    [Abstract] PDF Full Version

  • Chen, S., Chen, J., Shi, H., Wei, M., Castaneda-Castellanos, D. R., Bultje, R. S., Pei, X., Kriegstein, A. R., Zhang, M., and Shi, S.-H. (2013) "Regulation of Microtubule Stability and Organization by Mammalian Par3 in Specifying Neuronal Polarity" Dev Cell 24, 26-40.
    [Abstract] PDF Full Version

  • Wei, Z. and Zhang, M. (2013) "Decorating proteins with "sweets" is a flexible matter" Structure 21, 1-2
    [Abstract] PDF Full Version

  • Pan, Z., Shang, Y., Jia, M., Zhang, L., Xia, C., Zhang, M., Wang, W., and Wen, W. (2013) "Structural and Biochemical Characterization of the Interaction between LGN and Frmpd1" J Mol Biol. 425, 1039-1049.
    [Abstract] PDF Full Version

  • Chen, J. and Zhang, M. (2013) "The Par3/Par6/aPKC Complex and Epithelial Cell Polarity" Exp Cell ResExp Cell Res 319, 1357-1364. [review article]
    [Abstract] PDF Full Version

 

Year 2012
  • Lu, Q., Ye, F., Wei, Z., Wen, Z., and Zhang, M. (2012) "Antiparallel Coiled Coil-Mediated Dimerization of Myosin X" PNAS,Sept 10,2012.
    [Abstract] PDF Full Version

  • Zhu, J., Shang, Y., Chen, J., and Zhang, M. (2012) "Structure and Function of the Guanylate Kinase-like Domain of the MAGUK Family Scaffold Proteins"Frontiers in Biology , Oct,2012,(invited review)
    [Abstract] PDF Full Version

  • Yu, C, Lou, J., Wu, J., Pan, L., ., Feng, W.*, and Zhang, M.* (2012) "Membrane-induced lever arm expansion allows myosin VI to walk with large and variable step sizes" J Biol Chem., August 30, 2012  (*Co-corresponding authors)
    [Abstract] PDF Full Version

  • Jia, M., Li, J., Zhu, J., Wen, W., Zhang, M.*, and Wang, W.* (2012) "Structure and Biochemical Characterizations of LGN GoLoco/Gai Interaction Suggest Scaffolding and Ga Signaling Roles of LGN in Asymmetric Cell Division" J Biol Chem , September 5,2012 (*Co-corresponding authors)
    [Abstract] PDF Full Version

  • Xu, Z., Wei, Z.., Zhou, J., Ye, F., Lo, C. W. S., Wu, J., Wang, F., Lau, C. C. F., Nangle, L., Chiang, K. P., Yang, X.-L., Zhang, M., and Schimmel, P. (2012) "Internally deleted human tRNA synthetase suggests evolutionary pressure for repurposing" Structure, 20,1470-1477, 5 September 2012
    [Abstract] PDF Full Version

  • Wu, L., Pan, L., Zhang, C., and Zhang, M. (2012) "Large protein assemblies formed by multivalent interactions between cadherin23 and harmonin suggest a stable anchorage structure at the tip link of stereocilia" J Biol Chem (published August 8, 2012; doi:10.1074/jbc.M112.378505)
    [Abstract] PDF Full Version

  • Huo, L., Yue, Y., Yu, J., Yu, Y., Ye, F., Xu, T.*, Zhang, M.*, and Feng, W.* (2012) "The CC1-FHA tandem as a central hub for controlling the dimerization and activation of kinesin-3 KIF1A" Structure (published online on Aug. 2). (*Co-corresponding authors)
    [Abstract] PDF Full Version

  • Jin, H., Li, L., Xu, J., Zhen, F., Zhu, L., Liu, P., Zhang, M., Zhang, W., and Wen, Z. (2012) "Runx1 regulates embryonic myeloid fate choice in zebrafish through a negative feedback loop that confines Pu.1 expression" Blood 119, 5239-5249.
    [Abstract] PDF Full Version

  • Wang, C., Shang, Y., Yu, J., and Zhang, M. (2012) "Substrate Recognition Mechanism of Atypical Protein Kinase Cs Revealed by the Structure of PKCι in complex with a Substrate Peptide from Par-3" Structure 20, 791-801
    [Abstract] PDF Full Version

  • Li, X., Funderburk, S. F., Che, K. H., Pan, L., Zhang, M., Yue, Z., and Zhao, Y. (2012) "Imperfect and metastable dimer interface of Beclin 1 coiled coil domain is critical for association with Atg14L and UVRAG" Nat Comms 3:662 doi:10.1038/ncomms1648
    [Abstract] PDF Full Version

  • Wang, C., Yu, C., Ye, F., Wei, Z., and Zhang, M. (2012) "Structure of the ZU5-ZU5-UPA-DD tandem of ankyrin-B reveals interaction surfaces necessary for ankyrin function" PNAS 108, 3572-3577
    [Abstract] PDF Full Version

  • Pan, L. and Zhang, M. (2012) "A Structural Biology Perspective of the Usher Syndrome I Protein Complex Assembly" Physiology 27, 25-42
    [Abstract] PDF Full Version

 

Year 2011
  • Zhu, J., Shang, Y., Xia, C., Wang, W., Wen, W., and Zhang, M., (2011) "Guanylate Kinase Domains of the MAGUK Family Scaffold Proteins as Specific Phospho-Protein Binding Modules" EMBO J 30,4986-97
    [Abstract] PDF Full Version

  • Pan, L., Chen, J., Yu, J., Yu, H., and Zhang, M. (2011) "The Structure of the PDZ3-SH3-GuK Tandem of ZO-1 Suggests a Supramodular Organization of the MAGUK Family Scaffold Protein Core". J Biol Chem. 286, 40069-74
    [Abstract] PDF Full Version

  • Lu, Q., Yu, J., Yan, J., Wei, Z., and Zhang, M. (2011) "Structural basis of the myosin X PH1N-PH2-PH1C tandem as a specific and acute cellular PI(3,4,5)P3 sensor " Mol. Biol. Cell 22 , 4268-78
    [Abstract] PDF Full Version

  • Wei, Z., Zheng, S., Spangler, S A., Yu, C., Hoogenraad, C. C., and Zhang, M. (2011) "Liprin-mediated Large Signaling Complex Organization Revealed by the Liprin-α/CASK and Liprin-α/Liprin-β Complex Structures. " Mol. Cell 43, 586-598
    [Abstract] PDF Full Version

  • Zhu, J., Wen, W., Zheng, Z., Shang, Y., Wei, Z., Xiao, Z., Pan, Z., Du, Q., Wang, W., and Zhang, M. (2011) "LGN/mInsc and LGN/NuMA Complex Structures Suggest Distinct Functions in Asymmetric Cell Division for the Par3/mInsc/LGN and Gαi/LGN/NuMA Pathways" Mol. Cell 43, 418-431
    [Abstract] PDF Full Version

  • Liu, W., Wen W., Wei, Z., Yu, J., Ye, F., Liu, C-H., Hardie, R. C., and Zhang, M.(2011) "The INAD scaffold is a dynamic, redox-regulated modulator of signalling in the Drosophila eye" Cell 145,1088-1101
    [Abstract] PDF Full Version

  • Huo, L., Wen, W., Wang, R., Kam, C., Xia, J., Feng, W., and Zhang, M.(2011) "Cdc42-dependent formation of the ZO-1/MRCKb complex at the leading edge controls cell migration" EMBO J. 30, 665-678
    [Abstract] PDF Full Version

  • Wei, Z., Yan, J., Lu, Q.,Pan, L., and Zhang, M.(2011) "Cargo Recognition Mechanism of Myosin X Revealed by the Structure of its Tail MyTH4-FERM Tandem in Complex with the DCC P3 Domain" PNAS 108, 3572-3577
    [Abstract] PDF Full Version

  • Wu, L., Pan, L., Wei, Z., and Zhang, M.(2011) "Structure of MyTH4-FERM Domains in Myosin VIIa Tail Bound to Cargo" Science 331,757-760
    [Abstract] PDF Full Version

Year 2010
  • Wenyu Wen, Jiang Yu, Lifeng Pan, Zhiyi Wei, Jingwei Weng, Wenning Wang, Yan Shan Ong, Ton Hoai Thi Tran, Wanjin Hong and Zhang, M. (2010) " Lipid-Induced Conformational Switch Controls Fusion Activity of Longin Domain SNARE Ykt6." Mol. Cell, 37 383-395
    [Abstract] PDF Full Version

  • Shi, Y., Yu, J., Yuan, J., Pan, L. Shen, C., Xia, J and Zhang, M. (2010) &quot Redox-regulated lipid membrane binding of the PICK1 PDZ domain of the two Usher syndrome proteins." Biochemistry
    [Abstract] PDF Full Version

  • Wei, Z. and Zhang, M. (2010) " A Structural Approach to Decipher the Neurexin and Neuroligin Splice Isoform Code" Neuron 67 ,1-2.
    [Abstract] PDF Full Version

  • Yan J, Pan L, Chen X, Wu L, and Zhang M (2010) " The Structure of the harmonin/sans complex reveals an unexpected interaction mode of the two Usher syndrome proteins" PNAS 107 4040-5.
    [Abstract] PDF Full Version

  • Wang, C., Pan, L, Chen, J., and Zhang, M. (2010) " Extensions of PDZ domains as important structural and functional elements" Protein & Cell 1 ,737-751.
    [Abstract] PDF Full Version

  • Ma. W., Shang, Y., Wei, Zi., Wen, W. Wang, W., and Zhang, M. (2010) " Phosphorylation of DCC by ERK2 is Facilitated by Direct Docking of the Receptor P1 Domain to the Kinase" Structure 18 ,1502-1511.
    [Abstract] PDF Full Version

  • Diao, Y., Liu, W., Wong, C., Wang, X., Lee, K., Cheung, P.-Y., Pan,L., Xu, T., Han, J. Yates III, J.,Zhang, M. , and Wu,Z.(2010) &quot An Oxidation-induced Intramolecular Disulfide Bond Inactivates MKK6 by Inhibiting ATP Binding" PNAS 107 ,20974-20979.
    [Abstract] PDF Full Version

  • Guenebeaud, C., Castets, M., Delloye-Bourgeois, C., Guix, C.,Eisenberg-Lerner, A., Shohat, G.,Zhang, M., Kimchi, A.., Bernet, A., and Mehlen, P.(2010) & "The dependence receptor UNC5H2 triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase"; Mol. Cell 40 ,863-876.
    [Abstract] PDF Full Version

Year 2009
  • Feng, W. and Zhang, M. (2009) " Organization and Dynamics of PDZ Domain-Related Supramodules in the Postsynaptic Density." Nat. Rev. Neurosci. 10, 87-99
    [Abstract] PDF Full Version

  • Wang, W., Weng, J., Zhang, X., Liu, M. and Zhang, M. (2009) " Creating conformational entropy by increasing inter-domain mobility in ligand binding regulation: a revisit to N-terminal tandem PDZ domains of PSD-95." J. Am. Chem. Soc. 131, 787-796
    [Abstract] PDF Full Version

  • Wang, R., Wei, Z., Jin, H., Wu, H., Yu, C., Wen, W., Chan, L.-N., Wen, Z. and Zhang, M. (2009) " Auto-inhibition of UNC5b Revealed by the Cytoplasmic Domain Structure of the Netrin Receptor." Mol Cell. 33 692-703
    [Abstract] PDF Full Version

  • Lifeng Pan., Yan, J., Wu, L. and Zhang, M. (2009) " Assembling Stable Hair-Cell Tip Link Complex via Multi-dentate Interactions between Harmonin and Cadherin23" PNAS. 106 5575-5580
    [Abstract] PDF Full Version

  • Yu, C., Feng, W., Wei, Z., Miyanoiri, Y., Wen, W., Zhao, Y., and Zhang, M. (2009) " Myosin VI undergoes cargo-mediated dimerization" Cell. 138 537-548
    [Abstract] PDF Full Version
Year 2008
  • Long, J.-F., Wei, Z., Feng, W., Zhao, Y.-X., and Zhang, M.(2008) "Supramodular Nature of GRIP1 Scaffold Revealed by the Crystal Structure of Its PDZ12 Tandem in Complex with the Carboxyl Tail of Fras1". J. Mol. Biol. 375, 1457-1468.
     [Abstract] PDF Full Version
     
  • Song, C., Wen, W., Rayala, S. K., Singh, R. R., Chen, M., Ma, J., Talukder, A. H., and Zhang, M.Kumar, R.(2008) "Serine 88 Phosphorylation of the Dynein Light Chain 1 is a Molecular Switch for its Dimerization Status and Functions". J. Biol. Chem. 283, 4004-4013.
     [Abstract] PDF Full Version
     
  • Yan, J., Wen, W., Chan, L.-N., and Zhang, M.(2008) "Split Pleckstrin Homology Domain-Mediated Cytoplasmic¨CNuclear Localization of PI3-Kinase Enhancer GTPase". J. Mol. Biol. 378, 425-435.
     [Abstract] PDF Full Version
     
  • Jia Chen, Lifeng Pan, Zhiyi Wei, Yanxiang Zhao and Zhang, M.(2008) "Domain-swapped dimerization of ZO-1 PDZ2 generates specific and regulatory connexin43-binding sites". EMBO J. 27, 2113-2123.
     [Abstract] PDF Full Version
     
  • Wan, J., Cheung, A. Y., Fu, W.-Y., Wu, C., and Zhang, M. Mobley, W. C., Cheung, Z. H., and Ip, N. Y. (2008) "Endophilin B1 as a novel regulator of nerve growth factor/ TrkA trafficking and neurite outgrowth". J. Neurosci. 28, 9002-9012.
     [Abstract] PDF Full Version
     
  • Feng, W., Wu, H, Chan, L.-N., and Zhang, M.(2008) "Par-3-mediated Junctional Localization of the Lipid Phosphatase PTEN is Required for Cell Polarity Establishment". J. Biol. Chem. 283, 23440-23449.
     [Abstract] PDF Full Version
     
  • Wen, W., Liu, W., Yan, J. and Zhang, M.(2008) "Structure basis and unconventional lipid membrane binding properties of the PH-C1 tandem of Rho-kinases". J. Biol. Chem. 283, 26263-26273.
     [Abstract] PDF Full Version
     
Year 2007
  • Feng, W., Wu, H., Chan, LN., and Zhang, M.(2007) "The Par-3 NTD adopts a PB1-like structure required for Par-3 oligomerization and membrane localization". EMBO J. 26, 2786-2796.
     [Abstract] PDF Full Version
     
  • Feng, W., Huang, S.,Wu, H., and Zhang, M.(2007) "Molecular basis of Bcl-xL's target recognition versatility revealed by the structure of Bcl-xL in complex with the BH3 domain of Beclin-1". J. Mol. Biol. 372, 223-235.
     [Abstract] PDF Full Version
     
  • Olsen, O., Funke, L., Long, J.F., Fukata, M., Kazuta, T., Trinidad, J. C., Moore, K. A., Misawa, H., Welling, P. A., Burlingame, A. L., and Zhang, M.(2007) "Renal defects associated with improper polarization of the CRB and DLG polarity complexes in MALS-3 knockout mice". J. Cell Biol. 179, 151-164.
     [Abstract] PDF Full Version
     
  • Pan, L. F., Wu, H., Shen, C., Shi, Y., Jin, W., Xia, J., and Zhang, M.(2007) "Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes". EMBO J. 26, 4576-4587.
     [Abstract] PDF Full Version
     
  • Wu, H, Feng, W., Chen, J., Chan, L.-N., Huang, S., and Zhang, M.(2007) "PDZ Domains of Par-3 as Potential Phosphoinositide Signaling Integrators". Mol. Cell. 28, 886-898.
     [Abstract] PDF Full Version
     
  • Zhang, M.(2007) "Scaffold proteins as dynamic switches". Nat. Chem. Biol. 3, 756-757.
     [Abstract] PDF Full Version
     
Year 2006
  • Wan, J., Zhang, W., Wu, L., Bai, T., and Zhang, M.(2006) "BS69 Is a Specific Adaptor in the Latent Membrane Protein 1-meadiated c-Jun N-terminal Kinase Pathway". Mol. Cell. Biol. 26, 448-456.
     [Abstract] PDF Full Version
     
  • Jin, W., Ge, W., Xu, J., Cao, M., Peng, L., Yung, W., Liao, D., Duan, S., and Zhang, M.(2006) "Lipid Binding Regulates PICK1s Synaptic Targeting, AMPA Receptor Trafficking and Synaptic Plasticity". J. Neurosci.26, 2380-2390.
     [Abstract] PDF Full Version
     
  • Wen, W., Yan, J., and Zhang, M.(2006) "Structural characterization of the split PH domain in phospholipase C-γ1 and its interaction with TRPC3". J. Biol. Chem.281, 12060-12068.
     [Abstract] PDF Full Version
     
  • Wen, W., Chen, L., Wu, H., Sun, X., and Zhang, M.(2006) "Identification of the yeast R-SNARE Nyv1p as a novel longin domain containing protein". Mol. Biol. Cell 10, 4282-4299.
     [Abstract] PDF Full Version
     
Year 2005
  • Lo, K. W.-H.*, Kan, H.-M*, Chan, L.-N., Xu, W.-G., Wang, K.-P., Wu, Z., Sheng, M., and Zhang, M.(2005) "The 8 dynein light chain binds to 53BP1 and mediates DNA damage-induced p53 nuclear accumulation". J. Biol. Chem. 280 8172-8179.
     [Abstract] PDF Full Version
     
  • Feng, W., Long, J., and Zhang, M.(2005) "A unified assembly mode revealed by the structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteins". Proc. Natl. Acad. Sci. USA 102, 6861-6866.
     [Abstract] PDF Full Version
     
  • Aouacheria, A., Navratil, V., Wen, W., Jiang, M., Mouchiroud, D., Gautier, C., Gouy, M., and Zhang, M.(2005) "In silico whole-genome scanning and characterization of tumour-associated nonsynonymous SNPs using EST data". Oncogene 24, 6133-6142.
     [Abstract] PDF Full Version
     
  • Long, J.-F., Feng, W., Wang, R., Chan, L.-N., Ip, F.C.F., Xia, J., Ip, N., and Zhang, M.(2005) "Auto-inhibition of X11s/Mints Scaffold Proteins Revealed by the Closed Conformation of the PDZ Tandem". Nat. Struct. Mol. Biol. 12, 722-728.
     [Abstract] PDF Full Version
     
  • Yan, J., Wen, W., Xu, W., Long, J.-F., Adams, M. E., Froehner, S.C, and Zhang, M.(2005) "Structure of the Split PH domain and Distinct Lipid Binding Properties of the PH-PDZ Supramodule of α1-Syntrophin". EMBO J. 24, 3985-3995.
     [Abstract] PDF Full Version
     
  • Yang, Z., Xu, K., Wang, L., Gu, H., Wei, H., and Zhang, M.(2005) "Self-assembly of Small Molecules Affords Multifunctional Supramolecular Hydrogels for Topically Treating Simulated Uranium Wounds". Chem. Comm. 35, 4414-4416.
     [Abstract] PDF Full Version
     
Year 2004
  • Feng, W.*, Long, J.-F*, Fan, J-S, Suetake, T, and Zhang, M.(2004) "Hetero-tetrameric L27 (Lin-2, Lin-7) domain complexes as organization platforms for supra-molecular assemblies". Nature Struct. Mol. Biol. 11, 475-480. (*: co-first authors).
     [Abstract] PDF Full Version
     
  • Xu, X.-F., Tan, Y.-W., Lam, L., Hackett, J., and Zhang, M.(2004) "NMR structure of a type IVb Pilin from Salmonella typhi and its assembly into Pilus". J. Biol. Chem. 279, 31599-31605.
     [Abstract] PDF Full Version
     
  • Romorini S., Piccoli G., Jiang M., Grossano P., Tonna N., Passafaro, M., Zhang, M. and Sala, C.(2004) "A functional role of PSD-95/GKAP complex in regulating Shank assembly and stability to synapses". J. Neurosci. 24, 9391-9404.
     [Abstract] PDF Full Version
     
  • Cheung, P.-Y., Zhang, Y., Long, J.-F., Lin, S., Zhang, M., Jiang, Y. and Wu, Z.(2004) "p150Glued, dynein and microtubules are specifically required for activation of MKK3/6 and p38 MAPKs". J. Biol. Chem. 279, 45308 -45311.
     [Abstract] PDF Full Version
     
Year 2003
  • Long, J.-F., Tochio, H., Wang, P., Fan, J.-S, Sala, C., Niethammer, M., Sheng, M., and Zhang, M.(2003) "Supramodular Structure and Synergistic Target Binding of the N-terminal Tandem PDZ Domains of PSD-95". J. Mol. Biol. 327, 203-214.
     [Abstract] PDF Full Version
     
  • Zhang, M., and Wang, W.(2003) "Organization of Signaling Complexes by PDZ-domain Scaffold Proteins ". Acc. Chem. Res 36(7), 530-538.
     [Abstract] PDF Full Version
     
  • Wang, W., Lo W.-H., Kan H-M, Fan J-S, and Zhang, M.(2003) "Structure of the Monomeric 8-kDa Dynein Light Chain and Mechanism of the Domain-swapped Dimer Assembly". J. Biol. Chem. 278, 41491 - 41499.
     [Abstract] PDF Full Version
     
  • Fang, M.,Tao, Y.H., He, F., and Zhang, M.(2003) "Synaptic PDZ domain-mediated protein interactions are disrupted by inhalational anesthetics". J. Biol. Chem. 36669 - 36675.
     [Abstract] PDF Full Version
     
  • Feng, W., Shi, Y., Li, M., and Zhang, M.(2003) "Structure of tandem PDZ repeats in glutamate receptor interacting proteins reveals a novel mode of PDZ domain-mediated target binding". Nature Struct. Biol. 10(11), 972-978.
     [Abstract] PDF Full Version
     
Year 2002
  • Fan, J.-S, Zhang, Q., Tochio, H., and Zhang, M.(2002) "Backbone Dynamics of the 8 kDa Dynein Light Chain Dimer Reveals Molecular Basis of Proteins Functional Diversity". J. Biomol. NMR 23, 103-114.
     [Abstract] PDF Full Version
     
  • Galigniana, M.D., Harrell, J. M., Murphy, P. J., Chinkers, M., Radanyi, C., Renoir, J.-M., Zhang, M., and Pratt, W. B. (2002) "Binding of hsp90-associated Immunophilins to Cytoplasmic Dynein: Direct Binding and in vivo Evidence that the Peptidylpropyl Isomerase Domains is a Dynein Interaction Domain". Biochemistry 41, 13602-13610.
     [Abstract] PDF Full Version
     
  • Feng, W., Fan, J.-S., Jiang, M., Shi, Y.-W., and Zhang, M. (2002) "PDZ7 of Glutamic Receptor Interacting Protein Binds to its Target via a Novel Hydrophobic Surface Area". J. Biol. Chem 277, 41140-41146.
     [Abstract] PDF Full Version
     
  • Fan, J.-S., and Zhang, M. (2002) "Signaling Complex Organization by PDZ Domain Proteins". NeuroSignals 11, 315-321. (invited review)
     [Abstract] PDF Full Version
     
Year 2001
  • Fan, J.-S, Zhang, Q., Tochio, H. Li, M., and Zhang, M. (2001) "Structural Basis of Diverse Sequence-dependent Target Recognition by the 8 kDa Dynein light Chain". J. Mol. Biol 306, 97-108.
     [Abstract] PDF Full Version
     
  • Lo, K. W.-H., Naisbitt, S., Fan, J.-S, Sheng, M. and Zhang, M. (2001) "The 8 kDa Dynein Light Chain Binds to Its Targets via a Conserved (K/R)XTQT Motif". J. Biol. Chem 276, 14059-14066.
     [Abstract] PDF Full Version
     
  • Mok, Y.-K., Lo, K. W.-H., and Zhang, M. (2001) "Structure of Tctex-1 and its Interaction with Cytoplasmic Dynein Intermediate Chain". J. Biol. Chem. 276, 14067-14074.
     [Abstract] PDF Full Version
     
  • Tochio, H., Tsui, M. M. K., Banfield, D. K., and Zhang, M. (2001) "An Auto-Inhibitory Mechanism for Non-Syntaxin SNARE Proteins Revealed by the Structure of Ykt6p". Science 293, 698-702.
     [Abstract] PDF Full Version
     
  • Zhang, Q., Fan, J.-S., and Zhang, M. (2001) "Inter-domain Chaperoning Between PSD-95, Dlg, and ZO-1 (PDZ) Domains of Glutamate Receptor Interacting Proteins". J. Biol. Chem. 276, 43216-43220.
     [Abstract] PDF Full Version
     
  • Wu F, Zhang M, and Gong W. (2001) "Crystallization and preliminary crystallographic studies of an apoptosis-linked calcium-binding protein ALG-2". Acta Crystallographica D Biol Crystallography 57, 1162-1163.
     [Abstract] PDF Full Version
     
Year 2000
  • Tochio, H., Hung, F., Li, M., Bredt, D. S., and Zhang, M. (2000) "Solution Structure and Backbone Dynamics of the Second PDZ Domain of Postsynaptic Density-95". J. Mol. Biol. 295, 225-237.
     [Abstract] PDF Full Version
     
  • Wang, P., Zhang, Q., Tochio, H., Fan, J.-S., and Zhang, M. (2000) "Formation of a Native Like b-Hairpin Finger Structure of a Peptide from the Extended PDZ Domain of Neuronal Nitric Oxide Synthase in Aqueous Solution". Eur. J. Biochem. 267, 3116-3122.
     [Abstract] PDF Full Version
     
  • Wang, X., Ching, Y.-P, Lam, W.-H., Qi, Z., Zhang, M., and Wang, J. H. (2000) "Identification of a Common Protein Association Region in the Neuronal Cdk5 Activator". J. Biol. Chem. 275, 31763-31769.
     [Abstract] PDF Full Version
     
Year 199X
  • Chin, C.-T., Ohki, S., Tang, D., Cheng, H.-C., Wang, J. H., and Zhang, M. (1999) "Identification and Structural Characterization of a Cdk Inhibitory Peptide Derived from Neuronal Specific Cdk5 Activator". J. Biol. Chem. 274, 7120-7127.
     [Abstract] PDF Full Version
     
  • Tochio, H., Zhang, Q., Mandal, P., Li., M., and Zhang, M. (1999) "Solution Structure of the Extended Neuronal Nitric Oxide Synthase PDZ Domain Complexed with an Associated Peptide". Nature Struct. Biol. 6, 417-421.
     [Abstract] PDF Full Version
     
  • Lo, K. W.-H., Zhang, Q., Li, M., and Zhang, M. (1999) "Apoptosis-linked Gene ALG-2 Is a New Member of Calpain Small Subunit Subfamily Ca2+-binding protein". Biochemistry 38, 7498-7508.
     [Abstract] PDF Full Version
     
  • Zhang, M. and Yuan, T. (1998) "Molecular Mechanisms of Calmodulin's Functional Versatility". Biochem. Cell Biol. 76, 313-323(invited).
     [Abstract] PDF Full Version
     
  • Tochio, H., Ohki, S., Zhang, Q., Li, M., and Zhang, M. (1998) "Solution Structure of a Protein Inhibitor of Neuronal Nitric Oxide Synthase". Nature Struct. Biol. 5, 965-969.
     [Abstract] PDF Full Version
     
  • Fan, J.-S., Zhang, Q., Li, M., Tochio, H., Yamazaki, T., Shimizu, M., and Zhang, M. (1998) "Protein Inhibitor of Neuronal Nitric Oxide Synthase (PIN) Binds to a 17 Amino Acid Residues Fragment of the Enzyme". J. Biol. Chem. 273, 33472-33481.
     [Abstract] PDF Full Version
     
  • Fan, J-S., Cheng, H.-C., and Zhang, M. (1998) "A Peptide Corresponding to the Residues Asp177 to Asn208 of Human Cyclin A Forms an a-helix". Biochem. & Biophys. Res. Commun 253, 621-627.
     [Abstract] PDF Full Version
     
  • Ohki, S., Ikura, M., and Zhang, M. (1997) "Identification of the Mg2+-binding Sites and Role of Mg2+ on Target Recognition by Calmodulin". Biochemistry 36, 4309-4316.
     [Abstract] PDF Full Version
     
  • Tang, D., Chun, A.C.S., Zhang, M. and Wang, J.H. (1997) "Cdk5 Activation and Binding Sequences of Neuronal Specific Cdk5 Activator -- Evidence of the Existence of Fold in Nck5a". J. Biol. Chem. 272, 12318-12327.
     [Abstract] PDF Full Version
     
  • Zhang, M., and Vogel, H. J. (1997) "Interaction of a Partial Calmodulin- Binding Domain of Caldesmon with Calmodulin". Prot. Pept Lett. 4, 291-297.
     [Abstract] PDF Full Version
     
  • Aramini, J. M., Hiraoki, T., Yazawa, M., Yuan, T., Zhang, M., and Vogel, H. J. (1996) "Lead-207 NMR: A Novel Probe for the Study of Calcium-Binding Proteins". J. Biol. Inorgan. Chem. 1, 39-48.
     [Abstract] PDF Full Version
     
  • Martin, S. R., Bayley, P. M., Brown, S. E., Porumb, T., Zhang, M. and Ikura, M. (1996) "Spectroscopic Characterization of a High-Affinity Calmodulin-Target Peptide Hybrid Molecule". Biochemistry 35, 3508-3517.
     [Abstract] PDF Full Version
     
  • Siivari, K., Zhang, M., Palmer, A. G., and Vogel, H. J. (1995) "NMR Studies of the MethionineMethyl Groups in Calmodulin". FEBS Lett. 366, 104-108.
     [Abstract] PDF Full Version
     
  • Vogel, H.J. and Zhang, M. (1995) "Protein Engineering and NMR Studies of the Methionine Residues of Calmodulin". Mol. Cell. Biochem. 149/150, 3-15.
     [Abstract] PDF Full Version
     
  • Zhang, M., Tanaka, T. and Ikura, M. (1995) "Calcium-induced Conformational Transition Revealed by the Solution Structure of Apo Calmodulin". Nature Struct. Biol. 2, 758-767.
     [Abstract] PDF Full Version
     
  • Zhang, M., Yuan, T.,Aramini, J. M., and Vogel, H. J. (1995) "Interaction of Calmodulin with it Binding Domain of Rat Cerebellar Nitric Oxide Synthase: A Multinuclear NMR Study". J. Biol. Chem. 270, 20901-20907.
     [Abstract] PDF Full Version
     
  • Zhang, M., Tanaka, T., Farrow, N.A., Kay, L.E. and Ikura, M. (1995) "Multidimensional NMR Studies of the Structure and Dynamics of Calcium Free Calmodulin". Prot. Eng. 8, S30.
     [Abstract] PDF Full Version
     
  • Zhang, M. and Vogel, H.J. (1994) "Characterization of the Calmodulin-binding Domain of Rat Cerebellar Nitric Oxide Synthase". J. Biol. Chem. 269, 981-985.
     [Abstract] PDF Full Version
     
  • Zhang, M., Huque, E. and Vogel, H.J. (1994) "Characterization of Trimethyllysine-115 in Calmodulin by Nitrogen-14 and Carbon-13 NMR". J. Biol. Chem. 269, 5099-5105.
     [Abstract] PDF Full Version
     
  • Zhang, M. and Vogel, H.J. (1994) "The Calmodulin-binding Domain of Caldesmon Binds to Calmodulin in an α-Helical Conformation". Biochemistry 33 ,1163-1171.
     [Abstract] PDF Full Version
     
  • Zhang, M. and Vogel, H.J. (1994) "Two Dimensional NMR Studies of Selenomethionyl Calmodulin". J. Mol. Biol. 239, 545-554.
     [Abstract] PDF Full Version
     
  • Zhang, M., Li, M., Wang, J. and Vogel, H.J. (1994) "The Effect of Met-Leu Mutations on Calmodulin's Ability to Activate Cyclic Nucleotide Phosphodiesterase". J.Biol.Chem. 269, 15546-15552.
     [Abstract] PDF Full Version
     
  • Zhang, M., Vogel, H.J. and Zwiers, H. (1994) "Nuclear Magnetic Resonance Studies of the Structure of B50/Neuromodulin and its interaction with Calmodulin". Biochem. Cell Biol. 72, 109-116.
     [Abstract] PDF Full Version
     
  • Zhang, M. Thulin, E. and Vogel, H. J.(1994) "Reductive methylation and pKa determination of the lysine side chains in calbindin D9k". J. Prot. Chem. 13, 527-535.
     [Abstract] PDF Full Version
     
  • Zhang, M., Fabian, H., Mantsch, H., and Vogel, H. J. (1994) "Isotope-Filtered Fourier Tranform Infrared Spectroscopy Studies of the Interaction of Calmodulin with its Target Peptides". Biochemistry 33, 10883-10888.
     [Abstract] PDF Full Version
     
  • Zhang, M. and Vogel, H.J. (1993) "Determination of the Side Chain pKa Values of the Lysine Residues in Calmodulin". J. Biol. Chem. 268, 22420-22428.
     [Abstract] PDF Full Version
     
  • Zhang, M., Yuan, T. and Vogel, H.J. (1993) "A Peptide Analog of the Calmodulin-binding Domain of Myosin Light Chain Kinase Adopts an α-Helical Structure in Aqueous Trifluoroethanol". Prot. Sci. 2, 1931-1937.
     [Abstract] PDF Full Version
     

 

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